BinCARD rabbit polyclonal, anti-human, mouse

Backgroud: function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 CARD domain.,subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol.,subunit:Associates with BCL10 by CARD-CARD interaction.,tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.,function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 CARD domain.,subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol.,subunit:Associates with BCL10 by CARD-CARD interaction.,tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.,

Synonyms: C9orf89, Bcl10-interacting CARD protein, BinCARD

Gene Name: C9orf89

Gene ID: 84270

SwissProt ID: Q96LW7

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.