BIRC5 polyclonal, anti-human, bovine, dog, pig

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Cancers, Cell Growth and Death, Replication and Repair

Description:
BIRC5 (Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor suvivin) is a component of the chromosomal passenger complex (CPC), a key regulator of mitosis that functions at the centromere to ensure correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. With RAN, survivin forms a scaffold for mitotic spindle formation to deliver the RAN effector TPX2 to microtubules. Survivin plsys a role in neoplasia. It inhibits caspase-3 and caspase-7, blocking a default induction of apoptosis in G2/M phase. It is expressed in fetal kidney, liver, lung, brain, adenocarcinomas, lymphomas, renal cell carcinoma cell lines.

Alternate Names: BIRC5, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor suvivin, Apoptosis inhibitor 4, Survivin variant, AP14, IAP4

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: O15392

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BIRC5.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.