BIRC6 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6127a
Background:
BIRC6 is a member of a family of proteins that inhibit apoptosis, likely through interference with activation of ICE-like proteases. BIRC6, which contains a single BIR domain and a ubiquitin-conjugating enzyme domain, is expressed in four of six brain cancers (gliomas), and one of five ovarian cancers in a variety of human cancer cell lines. Brain cancer cell lines that overexpress BIRC6 demonstrate multi-drug resistance BIRC6 may protect cancer cells from undergoing apoptosis and participate in tumorigenesis and drug resistance.
Other Names:
Baculoviral IAP repeat-containing protein 6, 632-, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE, Ubiquitin-conjugating BIR domain enzyme apollon, APOLLON, BIRC6, KIAA1289
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6127a was selected from the N-term region of human BIRC6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: BIRC6
Gene ID: 57448
Primary Accession: Q9NR09
Other Accession: NP_057336
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
BIRC6 is a member of a family of proteins that inhibit apoptosis, likely through interference with activation of ICE-like proteases. BIRC6, which contains a single BIR domain and a ubiquitin-conjugating enzyme domain, is expressed in four of six brain cancers (gliomas), and one of five ovarian cancers in a variety of human cancer cell lines. Brain cancer cell lines that overexpress BIRC6 demonstrate multi-drug resistance BIRC6 may protect cancer cells from undergoing apoptosis and participate in tumorigenesis and drug resistance.
Other Names:
Baculoviral IAP repeat-containing protein 6, 632-, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE, Ubiquitin-conjugating BIR domain enzyme apollon, APOLLON, BIRC6, KIAA1289
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6127a was selected from the N-term region of human BIRC6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: BIRC6
Gene ID: 57448
Primary Accession: Q9NR09
Other Accession: NP_057336
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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