BK channel (C-term) polyclonal, anti-human, mouse, rat, rabbit, sheep, bovine, dog, chicken, zebrafish, drosophila

Protein Family: Receptors and Channels

Pathway and Disease: Cell Communication, Development and Behavior, Membrane Transport, Nervous and Sensory Systems

Description:
The BK channel (calcium-activated potassium channel subunit alpha-1 or KCNMA1) is a potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). BK channel is also activated by the concentration of cytosolic Mg(2+). BK channel has a key role in controlling excitability in a numerous systems, such as smooth muscle contraction, tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD).

Alternate Names: Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, subfamily M subunit alpha-1, Maxi K channel, MaxiK, BK channel, K(VCA)alpha, BKCa channel, BKCA alpha, KCa1.1, Slowpoke homolog, slo homolog, Slo-alpha, Slo1, hSlo, KCNMA1, KCNMA, SLO

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q12791

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human BK Channel.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Wan XJ et al. 2015. Int J Biochem Cell Biol. PMID 25481230.