BLNK (clone 5G9), anti-human, mouse

Background:
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Immunology

Synonyms: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051

Immunogen: Purified recombinant fragment of human BLNK expressed in E. Coli.

Formulation: Ascitic fluid containing 0.03% sodium azide.

Storage:
4°C|-20°C for long term storage