BLNK monoclonal (Ascites), anti-human

Background:
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Other Names:
B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65, BLNK, BASH, SLP65

Target/Specificity:
This BLNK antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human BLNK.

Antigen Region:
150-178

Antigen Type: Synthetic Peptide

Gene Name: BLNK
Gene ID: 29760
Primary Accession: Q8WV28
NCBI Accession: NP_001107566.1;NP_001245369.1;NP_037446.1
Other Accession: NP_001107566.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.