Blood Group Antigen Lewis B (clone 2-25LE; same as LWB01 ), anti-human, guinea pig
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In stock
SKU
AC-AH10472
Catalog Number: AC-AH10472
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: 2-25LE; same as LWB01
Applications: IHC-P, IF
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: 2-25LE; same as LWB01
Applications: IHC-P, IF
Datasheet
Request Information
Background:
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
Other Names:
Galactoside 3(4)-L-fucosyltransferase, 2.4.1.65, Blood group Lewis alpha-4-fucosyltransferase, Lewis FT, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FUT3, FT3B, LE
Gene Name: FUT3 (HGNC:4014)
Gene ID: 2525
Primary Accession: P21217
Other Accession: 2525, 169238
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
Other Names:
Galactoside 3(4)-L-fucosyltransferase, 2.4.1.65, Blood group Lewis alpha-4-fucosyltransferase, Lewis FT, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FUT3, FT3B, LE
Gene Name: FUT3 (HGNC:4014)
Gene ID: 2525
Primary Accession: P21217
Other Accession: 2525, 169238
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