BMI1 polyclonal, anti-human

Background:
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

Synonyms: FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1

Cellular Location: Cytoplasm Nucleus

Immunogen:
Recombinant protein of human BMI1

Gene Symbol: BMI1

Gene ID: 648

Swiss prot: P35226

Calculated MW: 37kDa

Recommended dilution:
WB 1:500-2000, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.