BMI1 Polyclonal Antibody

Background:
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms:
BMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1, Bmi1

Immunogen: Recombinant fusion protein of human BMI1 (NP_005171.4).

Swissprot: P35226
Gene ID: 648

Calculated MW: 36 kDa
Observed MW: 42 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.