BMI1 polyclonal (C-term), anti-human
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In stock
SKU
AC-AP2513B
Catalog Number: AC-AP2513B
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB02926
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB02926
Applications: WB, IHC-P
Datasheet
Request Information
Background:
BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
Other Names:
Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51
Target/Specificity:
This BMI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1.
Antigen Region:
257-286
Antigen Type: Synthetic Peptide
Gene Name: BMI1
Gene ID: 100532731;648
Primary Accession: P35226
NCBI Accession: NP_001190991.1;NP_005171.4
Other Accession: P25916; Q5SDR3; Q32KX7
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
Other Names:
Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51
Target/Specificity:
This BMI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1.
Antigen Region:
257-286
Antigen Type: Synthetic Peptide
Gene Name: BMI1
Gene ID: 100532731;648
Primary Accession: P35226
NCBI Accession: NP_001190991.1;NP_005171.4
Other Accession: P25916; Q5SDR3; Q32KX7
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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