BMP-1 rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008],catalytic activity:Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Activity is increased by the procollagen C-endopeptidase enhancer protein.,function:Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD).,similarity:Belongs to the peptidase M12A family.,similarity:Contains 2 EGF-like domains.,similarity:Contains 5 CUB domains.,tissue specificity:Ubiquitous.,

Synonyms: Bone morphogenetic protein 1 (BMP-1, EC 3.4.24.19, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP)

Gene Name: BMP1 PCOLC

Gene ID: 649

SwissProt ID: P13497

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.