BMP-2 rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,

Synonyms: BMP2, BMP2A, Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A

Gene Name: BMP2

Gene ID: 650

SwissProt ID: P12643

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.