Bmp1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP1712a
Background:
The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.
Other Names:
Bone morphogenetic protein 1, BMP-1, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1712a was selected from the C-term region of human Bmp1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: BMP1
Gene ID: 649
Primary Accession: P13497
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.
Other Names:
Bone morphogenetic protein 1, BMP-1, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1712a was selected from the C-term region of human Bmp1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: BMP1
Gene ID: 649
Primary Accession: P13497
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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