BMP2 Polyclonal Antibody

Background:
Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor-beta (TGFB) superfamily. BMP2 is synthesized as a 60 kDa precursor that is processed in the secretory pathway to a small 18 kDa monomer; 2 monomers then associate to form the active 30 kDa homodimer, which binds to its receptor. There is also a 40-45 kDa form of BMP2, as an amino-terminal propeptide. BMP2 can induce bone formation and regeneration during early embryonic development. It is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction.

Research Area: Cancer, Cardiovascular, Signal Transduction, Stem Cells

Synonyms:
BDA2, BMP-2, BMP-2A, Bmp2, BMP2, BMP2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse BMP2

Swissprot: P12643,P21274,P49001

Calculated MW: 45 kDa
Observed MW: 45 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 2.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:200-1:800

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.hindawi.com/journals/bmri/2018/3874131/abs/