BMPR-II Rabbit polyclonal antibody, anti-human, mouse, rat, monkey

Background:
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs| which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors| but they require their respective type I receptors for signaling| whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension| both familial and fenfluramine-associated| and with pulmonary venoocclusive disea

Research Area: Cardiovascular, Signal transduction, Stem cells

Synonyms: BMPR-II, Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, EC 2.7.11.30, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year