BMPR2(NT) polyclonal, anti-human antibody
€285.00
In stock
SKU
AC-ABV11322-100
Catalog Number: AC-ABV11322-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, FC
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, FC
Datasheet
Request Information
Background:
BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.
Other Names:
BMPR2, PPH1, Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II
Primary Accession: Q13873
Gene Name: BMPR2
Gene ID: 659
BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.
Other Names:
BMPR2, PPH1, Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II
Primary Accession: Q13873
Gene Name: BMPR2
Gene ID: 659
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