Bombesin/GRP polyclonal, anti-human, rat and chicken

Quantity: 100 µl

Background:
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms:
GRP, BN, GRP-10, proGRP, preproGRP

Isotype: Rabbit Polyclonal

Immunogen:
Bombesin conjugated to BSA

Form: Serum containing 0.1% sodium azide

Specificity:
Bombesin/GRP

Reactivity: human, rat and chicken

Applications: Immunohistochemistry, suitable in frozen and paraffin sections, Immunofluorescence

Working DIlution: 1:100 to 1:150 using PAP; 1:20 to 1:40 (with FITC in immunofluorescence)

Positive Control:
Formalin-fixed paraffin and frozen sections of rat or chicken stomach

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Ekblas, E. et al. (1984) Reg. Pept. 9: 279-287
- Gomi T et al. (1994) Histochemistry 102: 425-431