Bombesin polyclonal, anti-human, frog, rat and mouse

Quantity: 100 µl

Background:
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms:
BN, GRP-10, proGRP, preproGRP

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic frog bombesin conjugated to bovine thyroglobulin

Form: Serum containing 0.1% sodium azide

Specificity:
Bombesin

Reactivity: human, frog, rat and mouse

Applications: Immunohistochemistry, suitable for frozen and paraffin sections

Working DIlution: 1:25 - 1:50 for immunohistochemistry, optimal dilution should be tested by serial dilution

Positive Control:
Gut (peripheral nerves), fetal lung

Storage: 2-8C for immediate use, or at -20C (aliquot)