Bone Sialoprotein polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BSP is also known as IBSP(integrin-binding sialoprotein). The protein encoded by this gene is a major structural protein of the bone matrix. Bone sialoprotein is an acidic glycoprotein of approximately 70 kD that undergoes extensive posttranslational modifications. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. The BSP gene is mapped to 4q22.1.

Description:
Rabbit IgG polyclonal antibody for Bone sialoprotein 2 (IBSP) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
BNSP antibody, Bone sialoprotein 2 antibody, Bone sialoprotein 2 precursor antibody, Bone sialoprotein II antibody, bone sialoprotein II; bone sialoprotein antibody, BSP antibody, BSP II antibody, BSPII antibody, Cell binding sialoprotein antibody, Cell-binding sialoprotein antibody, IBSP antibody, Integrin binding sialoprotein antibody, Integrin binding sialoprotein(bone sialoprotein II) antibody, integrin binding sialoprotein(bone sialoprotein, bone sialoprotein II) antibody, Integrin-binding sialoprotein antibody, SIAL_HUMAN antibody, SPII antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Bone Sialoprotein(17-34aa FSMKNLHRRVKIEDSEEN), different from the related rat and mouse sequences by three amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human Bone Sialoprotein(17-34aa FSMKNLHRRVKIEDSEEN), different from the related rat and mouse sequences by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.