BPI polyclonal, anti-human, zebrafish

Background:
The bactericidal permeability increasing protein (BPI) is an antibacterial and endotoxin-neutralizing molecule that is abundant in the granules of polymorphonuclear leukocytes (neutrophil granules). The 31.5-kb-long human BPI gene maps to chromosome 20q11.23-q12, contains 15 exons, and encodes a 456 amino acid protein. Epithelial cells which line mucosal surfaces are the first line of defense against bacterial invasion and infection. BPI localizes to the cell surface of epithelial cells and blocks endotoxin-mediated signaling, thereby protecting mucosal surfaces against gram-negative bacteria and their endotoxin. BPI, lipopolysaccharide binding protein (LBP), phospholipid transfer protein (PLTP), and cholesteryl ester transfer protein (CETP) constitutes a family of functionally related proteins.

Alternative Name:
BPI, Bactericidal permeability-increasing protein, bactericidal/permeability-increasing protein, BPI, BPI fold containing family D, member 1, BPIFD1, CAP 57, rBPI, recombinant BPI holoprotein, rBPI,

Application Dilution:
WB:1:1,000-1:2,000
FC:1:50-1:100

Specificity: BPI polyclonal antibody detects endogenous levels of BPI protein.

Immunogen:
recombinant protein

MW: 57 kDa

Swiss-Prot: P17213(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.