Brachyury polyclonal, anti-human, mouse

Background:
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. Genetic variations in T are associated with susceptibility to neural tube defects (NTD). NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.

Alternative Name:
TBXT, BRAC, Brachyury homolog, Brachyury protein, Bry, MGC104817, Protein T, SAVA, T, T brachyury homolog, T brachyury transcription factor, T Protein, T, brachyury homolog (mouse), TFT, Transcription factor T antibody

Application Dilution:
WB:1:500
IHC:1:50-1:200
FC:1:50-1:100
IP:1:10-1:50

Specificity: Brachyury polyclonal antibody detects endogenous levels of Brachyury protein.

Immunogen:
Recombinant protein within human Brachyury/ Bry aa 200-400.

MW: 47 kDa

Swiss-Prot: O15178 Human,P20293 Mouse

Purification & Purity:
Protein A purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.