BRAF (clone 2A10D7), anti-
€0.00
In stock
SKU
BT-MCA4697
Catalog Number: BT-MCA4697
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity:
Application(s): WB, IHC, FCM
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity:
Application(s): WB, IHC, FCM
Datasheet
Request Information
Background:
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Research Area: Cell Biology
Synonyms: NS7, B-raf, BRAF1, RAFB1, B-RAF1
Immunogen: Purified recombinant fragment of human BRAF (AA: 299-447) expressed in HEK293-6e.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Research Area: Cell Biology
Synonyms: NS7, B-raf, BRAF1, RAFB1, B-RAF1
Immunogen: Purified recombinant fragment of human BRAF (AA: 299-447) expressed in HEK293-6e.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
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