BRCA1 (clone BRCA1/1472), anti-human
€0.00
In stock
SKU
AC-AH13528
Catalog Number: AC-AH13528
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: BRCA1/1472
Applications: IF, FC, E
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: BRCA1/1472
Applications: IF, FC, E
Datasheet
Request Information
Background:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Other Names:
BRCA1; Breast and ovarian cancer susceptibility protein 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; PSCP; RING finger protein 53; RNF53
Antigen Type:
Recombinant protein
Gene Name: BRCA1
Gene ID: 672
Primary Accession: P38398
Other Accession: 194143
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Other Names:
BRCA1; Breast and ovarian cancer susceptibility protein 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; PSCP; RING finger protein 53; RNF53
Antigen Type:
Recombinant protein
Gene Name: BRCA1
Gene ID: 672
Primary Accession: P38398
Other Accession: 194143
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