BRCA1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BRCA1, also known as BRCC1, is a gene which mapping to 17q21.3. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. In addition to it, BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by direct mutation or by alterations in gene expression.

Description:
Rabbit IgG polyclonal antibody for Breast cancer type 1 susceptibility protein (BRCA1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
BRAC 1 antibody, BRCA 1 antibody, BRCA1 antibody, BRCA1/BRCA2 containing complex subunit 1 antibody, BRCA1/BRCA2-containing complex, subunit 1 antibody, BRCA1_HUMAN antibody, BRCAI antibody, BRCC 1 antibody, BRCC1 antibody, Breast and ovarian cancer susceptibility protein 1 antibody, Breast Cancer 1 antibody, Breast Cancer 1 Early Onset antibody, Breast cancer type 1 susceptibility protein antibody, Breast Ovarian Cancer Susceptibility antibody, Breast Ovarian Cancer Susceptibility antibody, BROVCA1 antibody, IRIS antibody, Papillary Serous Carcinoma Of The Peritoneum antibody, PNCA4 antibody, PPP1R53 antibody, Protein phosphatase 1 regulatory subunit 53 antibody, PSCP antibody, RING finger protein 53 antibody, RING finger protein 53 antibody, RNF53 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human BRCA1 recombinant protein (Position: E1661-Y1863). Human BRCA1 shares 65% and 66% amino acid (aa) sequence identity with mouse and rat BRCA1, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.