BRCA1 polyclonal, anti-human, mouse, rat, monkey, pig
€362.00
In stock
SKU
200160
Protein Family: Enzymes, Ubiquitins
Pathway and Disease: Cancers, Folding, Sorting and Degradation, Replication and Repair, Signal Transduction
Description:
Breast cancer type 1 susceptibility protein (BRCA1) plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BRCA1 are a cause of genetic susceptibility to breast and ovarian cancers.
Alternate Names: Breast cancer type 1 susceptibility protein, RING finger protein 53, BRCA1, RNF53
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: P38398, NP_009225
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BRCA1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 12.5% glycerol with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cancers, Folding, Sorting and Degradation, Replication and Repair, Signal Transduction
Description:
Breast cancer type 1 susceptibility protein (BRCA1) plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BRCA1 are a cause of genetic susceptibility to breast and ovarian cancers.
Alternate Names: Breast cancer type 1 susceptibility protein, RING finger protein 53, BRCA1, RNF53
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: P38398, NP_009225
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BRCA1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 12.5% glycerol with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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