BRG1 (clone 6D7-F7-B6), anti-human, mouse

Background:
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila.Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI,which is required for transcriptional activation of genes normally repressed by chromatin.In addition, this protein can bind BRCA1,as well as regulate the expression of the tumorigenic protein CD44.Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2.Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq,May 2012]

Synonyms: BAF190, BAF190A, BRG1, CSS4, hSNF2b, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2

Cellular Location: Nucleus

Immunogen:
Purified recombinant human BRG1 protein fragments expressed in E.coli.

Gene Symbol: BRG1

Gene ID: 6597

Swiss prot: P51532

Calculated MW: 220kDa

Recommended dilution:
WB 1:1000, ICC 1:50

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.