BRI3BP Polyclonal Antibody

Background:
BRI3BP (BRI3 binding protein), also known as BNAS1, HCCR-1, I3-binding protein or cervical cancer 1 proto-oncogene-binding protein KG19, is a 251 amino acid multi-pass membrane protein. Though widely expressed, BRI3BP is found at highest levels in brain, kidney and liver where it localizes to the endoplasmic reticulum (ER) and is involved in ER structural dynamics and mitochondrial viability. Possessing pro-apoptotic properties and the ability to potentiate drug-induced apoptosis, BRI3BP overexpression has been shown to enhance caspase-3 and mitochondrial cytochrome c release in etoposide-treated human embryonic kidney 293T cells.

Research Area: Cancer, Cell Biology

Synonyms:
BNAS1, BRI3 binding protein, BRI3-binding protein, BRI3B, Bri3bp, Cervical cancer 1 proto oncogene binding protein KG19, Cervical cancer 1 proto-oncogene-binding protein KG19, cervical cancer oncogene binding protein, HCCR-2, HCCR1, HCCRBP-1, I3 binding protein, I3-binding protein, KG19

Immunogen: Synthetic peptide of human BRI3BP

Swissprot: Q8WY22
Gene Accession: NP542193

Calculated MW: 28 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.