BRWD1 Polyclonal Antibody

Background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
BRWD1, C21orf107, DCAF19, N143, WDR9

Immunogen: Recombinant fusion protein of human BRWD1 (NP_001007247.1).

Swissprot: Q9NSI6
Gene ID: 54014

Calculated MW: 13 kDa/248 kDa/257 kDa/262 kDa
Observed MW: 263 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:1000-1:3000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.