BST-2 rabbit polyclonal, anti-human, mouse, rat

Backgroud: Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008],disease:May play a role in B-cell activation in rheumatoid arthritis (RA).,function:May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation.,induction:During B-cell activation (at protein level), or by interferon alpha as part of entiviral state cellular program.,subunit:Homodimer.,tissue specificity:Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highy expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).,

Synonyms: BST2, Bone marrow stromal antigen 2, BST-2, HM1.24 antigen, Tetherin, CD317

Gene Name: BST2

Gene ID: 684

SwissProt ID: Q10589

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.