BTLA (clone 6F4), anti-human

Decription:
B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

Synonyms: B and T lymphocyte associated, Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3

Clone: 6F4

Isotype: Mouse IgG1

Immunogen: Ectodomain of human BTLA fused to human IgG Fc.

Reactivity: human

Specificity: Recognizes human BTLA.

Form: Purified, in PBS containing 10% glycerol.

Applications:
Flow Cytometry
ELISA
Functional Application: Inhibits interaction of BTLA to HVEM or UL144.

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)