BUB1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.

Synonyms: BUB1A, BUB1L, hBUB1

Cellular Location: Chromosome Nucleus centromere kinetochore

Immunogen:
Recombinant protein of human BUB1

Gene Symbol: BUB1

Gene ID: 699

Swiss prot: O43683

Calculated MW: 122kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.