BUB1 Polyclonal Antibody

Background:
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology

Synonyms:
BUB1, BUB1A, BUB1L, hBUB1

Immunogen: Recombinant fusion protein of human BUB1 (NP_004327.1).

Swissprot: O43683
Gene ID: 699

Calculated MW: 115 kDa/120 kDa/122 kDa
Observed MW: 133 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.