c Abl polyclonal, anti-human, rat

Quantity: 100 µg

Background:
c Abl is also called as ABL1. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene. Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Description:
Rabbit IgG polyclonal antibody for Tyrosine-protein kinase ABL1 (ABL1) detection. Tested with WB in Human, Rat.

Synonyms:
Abelson Murine Leukemia Viral Oncogene Homolog 1 antibody, Abelson murine leukemia viral v abl oncogene homolog 1 antibody, Abelson tyrosine protein kinase 1 antibody, Abl 1 antibody, ABL antibody, Abl protein antibody, ABL proto oncogene 1 non receptor tyrosine kinase antibody, Abl1 antibody, ABL1_HUMAN antibody, bcr/abl antibody, Bcr/c abl oncogene protein antibody, c abl oncogene 1 non receptor tyrosine kinase antibody, c abl oncogene 1 receptor tyrosine kinase antibody, JTK 7 antibody, JTK7 antibody, p150 antibody, Proto oncogene tyrosine protein kinase ABL1 antibody, Proto-oncogene c-Abl antibody, Transformation gene oncogene ABL antibody, Tyrosine-protein kinase ABL1 antibody, v abl Abelson murine leukemia viral oncogene homolog 1 antibody, v abl antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human c Abl (1020-1049aa ERIASGAITKGVVLDSTEALCLAISRNSEQ), different from the related mouse sequence by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human c Abl (1020-1049aa ERIASGAITKGVVLDSTEALCLAISRNSEQ), different from the related mouse sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.