c-ABL polyclonal, anti-mouse, rat

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Signaling Molecules and Interaction, Cancers, Development and Behavior, Cell Growth and Death, Infectious Diseases, Nervous and Sensory Systems

Description:
Proto-oncogene c-Abl (c-ABL) is a protein kinase that regulates key processes linked to cell growth and survival. c-ABL regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. C-ABL localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. c-ABL regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. A chromosomal aberration involving c-ABL1 is a cause of chronic myeloid leukemia.

Alternate Names: ABL1, Abelson murine leukemia viral oncogene homolog 1, Proto-oncogene tyrosine-protein kinase ABL1, c-ABL, p150, ABL

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500

Accession No.: P00519

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human c-ABL.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Ma Y et al. 2016. Diabetes Res Clin Pract. 113: 171-8. PMID 26810274.
[2] Chen X et al. 2013. Journal of Molecular Histology. March 21. PMID 23515840.