C/EBPß (clone EBPB-333), anti-human

Source:
A BALB/c mouse was immunized with human C/EBPβ recombinant protein.
Fusion partner: SP2/0.

Specifications:
EBP-333 reacts with C/EBPβ or CCAAAT/enhancer-binding protein beta, a transcription factor which is not only critical for normal macrophage functioning and differentiation, but affects a variety of other factors as well, such as cytokines (IL-6; IL-4; IL-5 and TNF-alpha), neurotransmitters and other neuronal factors and processes like muscle repair and the development of multi drug resistance in tumors (P-glycoprotein). Observations have implied that manipulation of the transcription factors involved may make it possible to modulate multidrug resistance, while leaving normal function of P-glycoprotein intact.

Species reactivity:
Positive: human.

Applications:
EBP-333 is suitable for immunohistochemistry on frozen sections and for Western blot. Other applications not tested.
Frozen sections: +
Western blot: +

Positive control: Macrophages.

References:
- Couturier, C et al, Arterioscler Thromb Vasc Biol. 20(12): 2559-65 (2000).
- Qin, L et al, Biomaterials59: 125-43 (2015).