c-Fgr polyclonal antibody, anti-human, mouse, rat

Background:
FGR is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein (FGR proto-oncogene, Src family tyrosine kinase) contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of FGR. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Research Area: Signal Transduction

Synonyms: FGR, SRC2, Tyrosine-protein kinase Fgr, Gardner-Rasheed feline sarcoma viral, v-fgr) oncogene homolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year