c-Fos Polyclonal Antibody

Background:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
Activator protein 1, AP 1, C FOS, Cellular oncogene c fos, Cellular oncogene fos, FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, FBJ murine osteosarcoma viral v fos oncogene homolog, FBJ Osteosarcoma Virus, FOS, FOS protein, FOS, G0 G1 switch regulatory protein 7, G0/G1 switch regulatory protein 7, G0S7, Oncogene FOS, p55, proto oncogene c Fos, Proto oncogene protein c fos, Proto-oncogene c-Fos, v fos FBJ murine osteosarcoma viral oncogene homolog

Immunogen: Synthesized peptide derived from the N-terminal region of human c-Fos

Swissprot: P01100

Calculated MW: 41 kDa
Observed MW: 62 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.