C-GRP (Calcitonin-Gene Related Peptide) polyclonal, anti-human, rat

Quantity: 100 µl

Background:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene

Synonyms:
CALCA, CT, KC, CGRP, CALC1, CGRP1, CGRP-I

Isotype: Rabbit Polyclonal

Immunogen:
Rat CGRP conjugated to BSA

Form: Serum containing 0.1% sodium azide

Specificity:
The antibody can be used for the diagnosis of medullary thyroid carcinomas.

Reactivity: human, rat

Applications: Immunohistochemistry of frozen and paraffin-embedded sections, no proteolytic treatment application. Immunocytochemistry

Working DIlution: 1:25 to 1:50 for immunohistochemistry

Positive Control:
Rat colon or pancreas

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Shahbazi F et al. (1998) Am J Physiol 44: R19-R28
- Mulder H et al. (1994) Gastroenterology 107: 712-719