c-Myc (clone IMD-3), anti-human

Protein Family: Transcription Factors

Pathway and Disease: Signaling Molecules and Interaction, Transcription, Cancers, Immune System, Cell Growth and Death, Signal Transduction

Description:
The Myc proto-oncogene protein (c-Myc) participates in the regulation of gene transcription. C-Myc is a transcription factor that binds DNA containing the core sequence 5'-CACGATG-3' but also in a non-specific manner. c-Myc activates genes related to cell growth. Overexpression of c-Myc is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC is a cause of a B-cell chronic lymphocytic leukemia. This antibody recognizes the C-term c-Myc peptide (EQKLISEEDL) used to express c-Myc-tagged fusion proteins.

Alternate Names: c-Myc, Myc proto-oncogene protein, Proto-oncogene c-Myc, Transcription factor p64, Class E basic helix-loop-helix protein 39, bHLHe39, MYC, BHLHE39

Application Notes: E: 1:100-1:500; WB: 1:25-1:100; IHC: 1:25-1:250; ICC: 1:25-1:250

Accession No.: P01106

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human c-Myc.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.