c-Myc polyclonal, anti-human

Protein Family: Transcription Factors, Epitope Tags

Pathway and Disease: Signaling Molecules and Interaction, Transcription, Signal Transduction

Description:
The Myc proto-oncogene protein (c-Myc) participates in the regulation of gene transcription. C-Myc is a transcription factor that binds DNA containing the core sequence 5'-CACGATG-3' but also in a non-specific manner. c-Myc activates genes related to cell growth. Overexpression of c-Myc is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC is a cause of a B-cell chronic lymphocytic leukemia. This antibody recognizes the C-term c-Myc peptide (EQKLISEEDL) used to express c-Myc-tagged fusion proteins.

Alternate Names: c-Myc, Myc proto-oncogene protein, transcription factor p64, MYC, Myc Tag, C-Myc Tag

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P01106

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the leucine zipper region of human c-Myc.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Wu Q et al. 2018. Mol Med Rep. 17(2): 2493-2500. PMID 29207109.