c-Myc polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol(2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.

Description:
Rabbit IgG polyclonal antibody for Myc proto-oncogene protein (MYC) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
AU016757 antibody, Avian myelocytomatosis viral oncogene homolog antibody, bHLHe39 antibody, c Myc antibody, c Myc Epitope Tag antibody, c Myc Tag antibody, Class E basic helix-loop-helix protein 39 antibody, MRTL antibody, Myc antibody, Myc Epitope Tag antibody, Myc protein antibody, Myc proto oncogene protein antibody, Myc proto-oncogene protein antibody, MYC_HUMAN antibody, Myc2 antibody, Myelocytomatosis oncogene antibody, Niard antibody, Nird antibody, Oncogene Myc antibody, OTTHUMP00000158589 antibody, Proto-oncogene c-Myc antibody, RNCMYC antibody, Transcription factor p64 antibody, Transcriptional regulator Myc-A antibody, V-Myc avian myelocytomatosis viral oncogene homolog antibody, v-myc myelocytomatosis viral oncogene homolog(avian) antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human c-Myc(421-439aa RKRREQLKHKLEQLRNSCA), different from the related mouse and rat sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.