c-Rel polyclonal, anti-human

Background:
c-Rel is the cellular cognate of v-Rel, the avian reticuloendotheliosis virus strain T transforming gene. v-Rel encodes a phosphoprotein that is located in the cytoplasm of transformed spleen cells and in the nucleus of non-transformed fibroblasts, in contrast to the c-Rel protein, which is cytoplasmic. c-Rel has been shown to represent a constituent of the κB site binding transcription factor NFκB, which plays a crucial role in the expression of immunoglobulin κ light chain gene. In contrast to c-Rel, v-Rel is truncated in its C-terminal transactivation domain and does not appear to function as a transcriptional transactivator. It has thus been postulated that v-Rel may interfere with the normal transcription of NFκB regulated genes and thus cause transformation by a mechanism analogous to v-ErbA, which binds to the thyroid hormone-responsive region in certain erythroid genes needed for differentiation, but cannot be activated by thyroid hormone.

Alternative Name:
REL, Avian reticuloendotheliosis, C REL, C Rel protein, c Rel proto oncogene protein, Oncogene REL, Oncogene REL avian reticuloendotheliosis, Proto-oncogene c-Rel, REL, REL, v rel avian reticuloendotheliosis viral oncogene homolog, v rel reticuloendotheliosis viral oncogene homolog, V rel reticuloendotheliosis viral oncogene homolog (avian),

Application Dilution:
WB:1:500
IHC:1:50-1:200

Specificity: c-Rel polyclonal antibody detects endogenous levels of c-Rel protein.

Immunogen:
Recombinant protein

MW: 68 kDa

Swiss-Prot: Q04864(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.