C15orf23 Polyclonal Antibody

Background:
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase . Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
KNSTRN, C15orf23, chromosome 15 open reading frame 23, HSD11, Kinastrin, Kinetochore-localized astrin-binding protein, Kinetochore-localized astrin/SPAG5-binding protein, Putative TRAF4-associated factor 1, SKAP, small kinetochore associated protein, T4AF1, TRAF4 associated factor 1, TRAF4-associated factor 1, Traf4af1

Immunogen: Recombinant Human Small kinetochore-associated protein protein

Swissprot: Q9Y448

Calculated MW: 35 kDa
Observed MW: 35 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.