C4BPB polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP16055c
Catalog Number: AC-AP16055c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB35297
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB35297
Applications: WB
Datasheet
Request Information
Background:
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Other Names:
C4b-binding protein beta chain, C4BPB
Target/Specificity:
This C4BPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB.
Antigen Region:
125-153
Antigen Type: Synthetic Peptide
Gene Name: C4BPB
Gene ID: 725
Primary Accession: P20851
NCBI Accession: NP_000707.1;NP_001017364.1;NP_001017365.1;NP_001017366.1;NP_001017367.1
Other Accession: NP_001017365.1;NP_001017367.1;NP_000707.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Other Names:
C4b-binding protein beta chain, C4BPB
Target/Specificity:
This C4BPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB.
Antigen Region:
125-153
Antigen Type: Synthetic Peptide
Gene Name: C4BPB
Gene ID: 725
Primary Accession: P20851
NCBI Accession: NP_000707.1;NP_001017364.1;NP_001017365.1;NP_001017366.1;NP_001017367.1
Other Accession: NP_001017365.1;NP_001017367.1;NP_000707.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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