C5AR1 Polyclonal Antibody

Background:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Research Area: Cancer, Metabolism, Immunology, Signal Transduction

Synonyms:
ANAPHYLATOXIN RECEPTOR, C5a anaphylatoxin chemotactic receptor, C5a anaphylatoxin receptor, C5A, C5a ligand, C5a-R, C5aR, C5AR, c5ar1, C5R1, CD88, CD88 antigen, Complement component 5 receptor 1, Complement component 5 receptor 2, Complement component 5a receptor 1

Immunogen: Fusion protein of human C5AR1

Swissprot: P21730
Gene Accession: BC008982

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.