C7 rabbit polyclonal, anti-human, mouse, rat

Backgroud: C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008],disease:Defects in C7 are a cause of component C7 deficiency (C7D) [MIM:217070]. Patients with C7D suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C7 is a constituent of the membrane attack complex. C7 binds to C5b forming the C5b-7 complex, where it serves as a membrane anchor.,online information:C7 mutation db,PTM:C7 has 28 disulfide bridges.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,similarity:Contains 2 TSP type-1 domains.,subunit:Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes.,

Synonyms: C7, Complement component C7

Gene Name: C7

Gene ID: 730

SwissProt ID: P10643

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.