C8orf4 Polyclonal Antibody

Background:
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal transduction, Stem cells

Synonyms:
C8orf4, CH004, Chromosome 8 open reading frame 4, Human thyroid cancer 1, MGC22806, TC-1, TC1, Thyroid cancer protein 1, Uncharacterized protein C8orf4

Immunogen: Fusion protein of human C8orf4

Swissprot: Q9NR00
Gene Accession: BC020623

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.96 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.