CA5B Polyclonal Antibody

Background:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.CA5B (Carbonic Anhydrase 5B) is a Protein Coding gene. Diseases associated with CA5B include Heart Conduction Disease and Heart Septal Defect. Among its related pathways are Nitrogen metabolism and Metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA5A.

Research Area: Metabolism, Signal Transduction

Synonyms:
CA VB, Carbonate dehydratase VB, Carbonic anhydrase 5B, mitochondrial, Carbonic anhydrase VB, Carbonic anhydrase VB, mitochondrial

Immunogen: Synthetic peptide of human CA5B

Swissprot: Q9Y2D0
Gene Accession: NP009151

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.4 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.