Cables1 polyclonal antibody, anti-human, mouse

Background:
CABLES1 encodes a protein (Cdk5 and Abl enzyme substrate 1) involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding different isoforms have been found for CABLES1.

Research Area: Cell Biology

Synonyms: CABLES1, CABLES, CDK5 and ABL1 enzyme substrate 1, Interactor with CDK3 1, Ik3-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year