CACNA1A polyclonal, anti-rat, human, mouse

Quantity: 100 µg

Background:
The CACNA1A gene, also known as CACNL1A4 or CaV2.1, encodes the transmembrane pore-forming subunit of the P/Q-type or CaV2.1 voltage-gated calcium channel(VGCC). Those channels not only mediate the entry of Ca(2+) ions into excitable cells but are also involved in a variety of Ca(2+)-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The channel activity is directed by the pore-forming alpha-1 subunit. CACNA1A is mapped to 19p13.2. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to(CAG)n-repeats. CACNA1A has been shown to interact with CACNB4.

Description:
Rabbit IgG polyclonal antibody for Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
APCA antibody, BI antibody, Brain calcium channel 1 antibody, Brain calcium channel I antibody, Cach4 antibody, Cacn3 antibody, Cacna1a antibody, Cacnl1a4 antibody, Calcium channel alpha 1A subunit antibody, Calcium channel L type alpha 1 polypeptide antibody, Calcium channel L type alpha-1 polypeptide isoform 4 antibody, Calcium channel voltage dependent, P/Q type alpha 1A subunit antibody, CAV2.1 antibody, EA2 antibody, FHM antibody, HPCA antibody, MHP antibody, MHP1 antibody, RAT brain class A antibody, RBA-I antibody, SCA6 antibody, Voltage-dependent P/Q-type calcium channel alpha-1A subunit antibody, Voltage-gated calcium channel alpha subunit Cav2.1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CACNA1A(430-447aa KTDLLNPEEAEDQLADIA), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the N-terminus of human CACNA1A(430-447aa KTDLLNPEEAEDQLADIA), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: human, mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.